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While multiple mechanisms of acquired resistance to CAR T cell therapy have been identified, including limited persistence of the CAR T cell product upon infusion and functional CAR T cell exhaustion, B cell neoplasms often evade recognition and killing by CAR T cells as they reduce or completely lose expression of the antigenic CAR target, a phenomenon that is commonly known as antigen loss. CD19-targeting CAR T cell therapy elicits objective responses (frequently complete remission) in 60-80% of patients with chemotherapy refractory disease, resulting in considerably improved progression-free survival (PFS) and overall survival (OS) in a patient population otherwise difficult to treat. With the exception of idecabtagene vicleucel and ciltacabtagene autoleucel, which recognize the MM-associated antigen TNF receptor superfamily member 17 (TNFRSF17, best known as BCMA), all FDA-approved CAR T cell products target CD19, which is expressed by both malignant and normal B cells. 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